073 Alternation of Sphingolipid Profile in Heart Failure and Therapeutic Potential of Sphingolipid Modifying Agent
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چکیده
منابع مشابه
Sphingolipid and Ceramide Homeostasis: Potential Therapeutic Targets
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction. Recent research has identified and characterised many of the key enzymes involved in sphingolipid metabolism and this has led to a heightened interest in the possibility of targeting these pro...
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Sphingolipids are essential components of membranes and important for cellular integrity. The main focus of research in the past years has been to demonstrate their role as second messengers. The yeast Saccharomyces cerevisiae is an excellent model for the study of sphingolipids, because the first steps of this metabolic pathway are highly conserved among fungal, plant and the animal kingdoms. ...
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Bioactive sphingolipids, such as sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (dhS1P) and ceramide, regulate a diverse array of cellular processes. Many of these processes are important components of wound-healing responses to tissue injury, including cellular apoptosis, vascular leak, fibroblast migration, and TGF-β signaling. Since over-exuberant or aberrant wound-healing res...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2020
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2020.09.080